Mood stabilizers include antiepileptic drugs (see Psychotropic properties of Antiepileptic drugs in patients with developmental disabilities).

Lithium has taken a secondary place in the treatment of bipolar affective disorder and major depressive disorder, especially in patients with epilepsy. Lithium is considered proconvulsant but has been used safely in patients with epilepsy and bipolar affective disorder.114 It has been associated also with encephalopathy when used in combination with carbamazepine.32 Lithium may be very useful in augmenting the effects of antiepileptic drugs for these disorders but should be used with caution in patients with epilepsy.

Adapted from: Barry JJ and Huynh N. Psychotropic drug use in patients with epilepsy and developmental disabilities. In: Devinsky O and Westbrook LE, eds. Epilepsy and Developmental Disabilities. Boston: Butterworth-Heinemann; 2001;205–217. With permission from Elsevier (

Authored By: 
John J. Barry MD
Nga Huynh PharmD
Reviewed By: 
Steven C. Schachter MD
Monday, May 31, 2004