Levetiracetam is rapidly and almost completely absorbed. Protein binding is <10 % and 66% of levetiracetam is excreted renally as unchanged drug. Metabolism of the remaining drug occurs by hydrolysis of the acetamide group and is not cytochrome P450 dependent.41

Effect of liver disease

The clearance of levetiracetam is reported to be unaffected by liver disease.

Effect of GI disease

The effect of GI disease on levetiracetam is unknown.

Adapted from: Garnett WR. Gastrointestinal and hepatic disease. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;63-74. 
With permission from Elsevier ( 

Reviewed By: 
Steven C. Schachter, MD
Monday, March 1, 2004