1. Greenblatt DJ, von Moltke LL, Ehrenberg BL, et al. Kinetics and dynamics of lorazepam during and after continuous intravenous infusion. Crit Care Med 2000;28:2750–2757.

2. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314–319.

3. Todd RB. Clinical Lectures on Paralysis, Disease of the Brain and Other Affections of the Nervous System. Philadelphia: Lindsay & Blakiston, 1855.

4. Edwards R, Schmidley JW, Simon RP. How often does a CSF pleocytosis follow generalized convulsions? Ann Neurol 1983;13:460–462.

5. Krumholz A, Grufferman S, Orr ST, et al. Seizures and seizure care in an emergency department. Epilepsia 1989;30:175–181.

6. Tardy B, Lafond P, Convers P, et al. Adult first generalized seizure: etiology, biological tests, EEG, CT scan, in an ED. Am J Emerg Med 1995;13:1–5.

7. Dalessio D. Seizure disorders and pregnancy. N Engl J Med 1984;312:559–563.

8. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia 1993;34:453–468.

9. Beghi E. Randomized clinical trial of the efficacy and safety of the treatment of the first unprovoked epileptic seizure. First Seizure Trial Group. Neuroepidemiology 1992;11:50.

10. Beghi E, Ciccone A. Recurrence after a first unprovoked seizure. Is it still a controversial issue? First Seizure Trial Group (first). Seizure 1993;2:5–10.

11. Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure. First Seizure Trial Group (FIRST Group). Neurology 1993;43:478–483.

12. Lowenstein DH, Alldredge BK. Status epilepticus. N Engl J Med 1998;338:970–976.

13. Degiorgio CM, Tomiyasu U, Gott PS, et al. Hippocampal pyramidal cell loss in human status epilepticus. Epilepsia 1992;33:23–27.

14. Aminoff MJ, Simon RP. Status epilepticus. Causes, clinical features and consequences in 98 patients. Am J Med 1980;69:657–666.

15. Jumao-as A, Brenner RP. Myoclonic status epilepticus: a clinical and electrographic study. Neurology 1990;40:1199–1202.

16. Krumholz A, Sung GY, Fisher RS, et al. Complex partial status epilepticus accompanied by serious morbidity and mortality. Neurology 1995;45(8):1499–1504.

17. Schwartz MS, Scott DF. Isolated petit mal status presenting de novo in middle age. Lancet 1971;2:1399–1402.

18. Van Zandycke M, Orban LC, Vander Eecken H. Acute prolonged ictal confusion (resembling petit mal status) presenting "de novo" in later life. Acta Neurol Belg 1980;80:174–179.

19. Yeo PT, Wodak J, Roe CJ, et al. Absence status: a report of two cases. Aust N Z J Med 1984;14:53–55.

20. Kaplan P. Nonconvulsive status epilepticus in the emergency room. Epilepsia 1996;37:643–650.

21. Kaplan P. Nonconvulsive status epilepticus. In S. Reich (ed), Zebras and Rare Birds. New York: Thieme Medical Publishers Inc, 1996;33–40.

22. Meierkord H, Will B, Fish D, et al. The clinical features and prognosis of pseudoseizures diagnosed using video-EEG telemetry. Neurology 1991;41:1643–1646.

23. Leis AA, Ross MA, Summers AK. Psychogenic seizures: ictal characteristics and diagnostic pitfalls. Neurology 1992;42:95–99.

24. Glosser G, Litt B. Nonepileptic seizures. In RT Johnson, JW Griffin, JC McArthur (eds), Current Therapy in Neurologic Disease, 6th ed. St. Louis: Mosby, 2002:58–60.

25. McArthur CL 3rd, Rooke CT. Are spinal precautions necessary in all seizure patients? Am J Emerg Med 1995;13:512–513.

26. Greenberg MK, Barsan WG, Starkman S. Neuroimaging in the emergency patient presenting with seizure. Neurology 1996;47:26–32.

27. Committee QS. Practice parameter: neuroimaging in the emergency patient presenting with seizure—summary statement. Quality Standards Subcommittee of the American Academy of Neurology in cooperation with American College of Emergency Physicians, American Association of Neurological Surgeons, and American Society of Neuroradiology. Neurology 1996;47:288–291.

28. Sheth RD. Frequency of neurologic disorders in the neonatal intensive care unit. J Child Neurol 1998;13:424–428.

29. Young GB, Jordan KG, Doig GS. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 1996;47:83–89.

30. Bleck TP, Smith MC, Pierre-Louis SJ, et al. Neurologic complications of critical medical illnesses. Crit Care Med 1993;21:98–103.

31. Jamerson BD, Dukes GE, Brouwer KL, et al. Venous irritation related to intravenous administration of phenytoin versus fosphenytoin. Pharmacotherapy 1994;14:47–52.

32. White M, Yalkowsky SH, Studies in phlebitis. III. Evaluation of diazepam and phenytoin. Pharm Res 1991;8:1341–1342.

33. Bauer LA. Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology 1982; 32:570–572.

34. Garnett W, Huffman J, Welsh S. Administration of Carbatrol (carbamazepine extended-release capsules) via feeding tubes. Paper presented at American Epilepsy Society Meeting, Miami, Florida; 1999.

35. Appleton R, Sweeney A, Choonara I, et al. Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. Dev Med Child Neurol 1995;37:682–688.

36. Temkin NR, Dikmen SS, Wilensky AJ, et al. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med 1990;323:497–502.

37. Clark DW. Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drugs 1985;29:342–375.

38. Duarte J, Macias S, Coria F, et al. Valproate-induced coma: case report and literature review. Ann Pharmacother 1993;27:582–583.

39. Panikkar GP, Gilman SM. Valproate-induced hyperammonemia in the psychiatric setting: 2 cases. J Clin Psychiatry 1999;60:557–559.

40. Young G, Jordan K, Doig G. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 1996;47:83–89.

41. Litt B, Wityk RJ, Hertz SH, et al. Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia 1998;39:1194–1202.

42. Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 1998;339 (12):792–798.

43. Towne AR, Waterhouse EJ, Boggs JG, et al. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 2000;54:340–345.

44. Lothman E. The biochemical basis and pathophysiology of status epilepticus. Neurology 1990;40[Suppl 2]:13–22.

45. Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA 1993;270:854–859.

46. Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology 1993;43:895–900.

47. Krishnamurthy KB, Drislane FW. Depth of EEG suppression and outcome in barbiturate anesthetic treatment for refractory status epilepticus. Epilepsia 1999;40:759–762.

48. Mirski MA, Williams MA, Hanley DF. Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus. Crit Care Med 1995;23:400–404.

49. Bleck TP. Management approaches to prolonged seizures and status epilepticus. Epilepsia 1999;40[Suppl 1]:S59–S63;discussion S64–S66.

50. Rabinowicz AL, Correale JD, Bracht KA, et al. Neuron-specific enolase is increased after nonconvulsive status epilepticus. Epilepsia 1995;36:475–479.

51. Wasterlain CG, Fujikawa DG, Penix L, et al. Patho- physiological mechanisms of brain damage from status epilepticus. Epilepsia 1993;34[Suppl 1]:S37–S53.

52. Drislane FW. Evidence against permanent neurologic damage from nonconvulsive status epilepticus. J Clin Neurophysiol 1999;16:323–331; discussion 353.

53. Holmes GL, Riviello JJ Jr. Midazolam and pentobarbital for refractory status epilepticus. Pediatr Neurol. 1999;20(4):259-64.

54. Iijima T, Nakamura Z, Iwao Y, et al. The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy. Anesth Analg. 2001;91(4):989–995.

Adapted from: Kolb SJ and Litt B. Management of epilepsy and comorbid disorders in the emergency room and intensive care unit. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;515–535. With permission from Elsevier (www.elsevier.com).

Authored By: 
Steven J. Kolb Md PhD
Brian Litt MD
Reviewed By: 
Steven C. Schachter MD
Saturday, May 1, 2004