Generic name Brand name Metabolism
Tricyclic antidepressants
amitriptyline Elavil CYP1A2/2D6, GT1A1
imipramine Tofranil CYP1A2/2C19, GT1A3
clomipramine Anafranil CYP1A2/2C19/2D6
desipramine Norpramin CYP2D6
doxepin Sinequan GT1A3/1A4
nortriptyline Pamelor CYP2D6
trimipramine Surmontil  
Selective serotonin reuptake inhibitors (SSRIs)
citalopram Celexa CYP2C19/2D6
fluoxetine Prozac CYP2D6/3A3/4
fluvoxamine Luvox CYP1A2/others
paroxetine Paxil CYP2D6/others
sertraline Zoloft CYP3A3/4
Monoamine oxidase inhibitors (MAOIs)
phenelzine Nardil  
tranylcypromine Parnate  
maprotiline Ludomil  
amoxapine Asendin  
bupropion Wellbutrin CYP2B1/2D6/3A4
mirtazapine Remeron CYP2D6
nefazodone Serzone CYP3A3/4
trazodone Desyrel  
venlafaxine Effexor CYP2D6
reboxetine Vestra CYP3A4

CYP = cytochrome P-450; GT = glucuronosyltransferase.

Adapted from: Koppel BS. Contribution of drugs and drug interactions (prescribed, over the counter, and illicit) to seizures and epilepsy. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;163.
With permission from Elsevier (

Authored By: 
Steven C. Schachter
Authored Date: