Generic name Brand name Metabolism
diazepam Valium CYP3A4/2C9/1A2
lorazepam Ativan CYP3A4, GT2B7
alprazolam Xanax CYP3A4/2C19
clonazepam Klonopin CYP3A3/4
oxazepam Serax  
chlordiazepoxide Librium  

CYP = cytochrome P-450; GT = glucuronosyltransferase.

Adapted from: Koppel BS. Contribution of drugs and drug interactions (prescribed, over the counter, and illicit) to seizures and epilepsy. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;163.
With permission from Elsevier (

Authored By: 
BS Koppel
Reviewed By: 
Steven C. Schachter MD
Monday, March 1, 2004