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Hello community. My partner was "diagnosed" with epilepsy, frontal lobe we were told, about 3 years ago. Over the span of those years she developed absent seizures and myoclonic seizures. Eventually, the myoclonic seizures stopped, not sure why but they did. She still suffers from the tonic clonic seizures, which occur approximately 2 weeks apart and absent seizures that last about 30 seconds, about every 20 minutes. Now, I put diagnosed in quotation marks because I have never been sure, nor have the doctors, that she has epilepsy. We have been to several week long EEGs; to name a few, Shands, and Tampa Gen., when come to find out, nothing showed irregular. Eventually, we moved to North Carolina, seen a nuero out in Ashville, and she made the diagnosis of frontal lobe epilepsy. Now, none of the AEDs she has been on have been of any help, and from what I've been told by her nuero, and what I have read, fronal lobe epilepsy responds well to certain AEDs, yet none have helped. Recently, after hiding for years, she tells me she has a pill addiction; tramadol and oxycodone. I happened to research side effects of tramadol and apparently it is known to cause seizures. Now, it stated that the seizures in their study occur approximately 24-48 hours after taking more than the recommended dose, I think 400mg. Has it been seen or recorded, that over years of abuse, they can either cause permanent brain disfunction, or cause seizures when a buildup of those chemicals reaches a certain point. Let me say that she well exceeds the daily dose of tramadol and include oxycodone as well, and likely has for some years now. I know that the tramadol has already presented some of the other side effects, ie; constipation, depression, appetite loss, so I need to know if it's possible for her situation to be a reasonable option. Any resources like medical journals or advice from experts will be greatly appreciated. I just need some answers.