Drug-Resistant Seizures


Seizures sometimes are not controlled with seizure medications. A number of different terms may be used to describe these including: “uncontrolled” or “drug-resistant.” How often does this happen?

  • Studies suggest that epilepsy fails to come quickly under control with medicines in about one-third of cases, but the true frequency depends upon the definition of uncontrolled.
  • Most epilepsy specialists agree that drug-resistant epilepsy is epilepsy for which seizures are frequent and severe enough, or the required therapy for them troublesome enough, to seriously interfere with quality of life.
  • However, in more recent years, the epilepsy community has recognized the need to continue striving for ‘no seizures’ and the best control possible.
    • Drug-resistant epilepsy occurs when a person has failed to become (and stay) seizure free with adequate trials of two seizure medications (called ASMs).
    • These seizure medications must have been chosen appropriately for the person’s seizure type, tolerated by the person, and tried alone or together with other seizure medications.

Seizures can be uncontrolled for four broad reasons.

  • The diagnosis is wrong.
  • The treatment is wrong.
  • Despite the best treatment, triggers or lifestyle factors may affect seizure control.
  • Properly diagnosed seizures do not respond to the best medical treatment.

Not all uncontrolled seizures are considered drug-resistant. For example:

  • If the diagnosis is corrected and seizures can be brought under control with a different treatment, then they would not be considered drug-resistant.
  • If triggers of lifestyle factors could be avoided or modified preventing breakthrough seizures, then medication therapy may work better. A person in this situation would not be considered drug-resistant, but different drug trials may be considered and non-drug treatments may be considered to help control seizures.

Imagine coming home at night after too much partying, and finding yourself unable to unlock your front door. One possibility is that you are at the wrong house.  Another is that you are using the wrong key. Or you really may be locked out. Perhaps someone inside has engaged the deadbolt. Drug-resistant epilepsy displays three similar categories.

An incorrect diagnosis of epilepsy, going to the wrong house, is more common than most people might think. One chart review study by Smith and colleagues in England found that 13% of patients referred for drug-resistant epilepsy did not have epilepsy. If seizures are not controlled, then a reasonable first question is: “Are the episodes really seizures?” A number of conditions can imitate seizures.

Authored By:

Joseph I. Sirven MD
Patty Osborne Shafer RN, MN
Robert Fisher MD, PhD

on Wednesday, November 06, 2013

Reviewed By:

Joseph I. Sirven MD
Patty Obsorne Shafer RN, MN

on Tuesday, January 21, 2014


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